Proton Pump Inhibitors | PPI

Proton Pump Inhibitors are potent medications that can block the acid production of the parietal cells of the stomach.

Currently available Proton Pump Inhibitors include:
Brand Name Generic Name Generic Available Over The Counter
Prilosec omeprazole Yes Prilosec OTC
Prevacid lansoprazole Yes Prevacid 24
Aciphex rabeprazole in 2013
Protonix pantoprazole Yes
Zegerid omeprazole/bicarbonate Yes Zegerid
Dexilant dexlansoprazole No

Prilosec, Prevacid, and Zegerid are available over the counter at low doses. Pantoprazole and omeprazole are available as generics. Rabeprazole is also available as a generic in Canada. All Delayed Release PPI are best taken on an empty stomach, because they are enteric coated. They also all need to be activated by a meal, so optimally are taken 30 to 60 minutes prior to eating a protein containing meal. Zegerid is immediate release and is activated by bicarbonate in the powder or capsule. All the others are delayed release and require food preferably half an hour to one hour after the medication to activate the drug. All the PPI are prodrugs that need to be activated. Taking it at the wrong time such as Nexium at bedtime may lead to disappointing results.

[xyz-ihs snippet=”Expertise”]

Photo By: Jeffrey Pang

About the Author

Long Island's Premier Center for evaluation and treatment of Reflux, GERD, IBS, Eosinophilic Esophagitis, and Laryngopharyngeal Reflux. Dr. Gutman is the Director of Reflux Care of New York. He is a leading authority in the fields of Gastroesophageal Reflux Disorder (GERD), Laryngopharyngeal Reflux (LPR), Irritable Bowel Syndrome (IBS), Eosinophilic Esophagitis, and Non Cardiac Chest Pain. Dr. Gutman's approach to complicated digestive problems, utilizing a breadth of clinical experience with state of the art technologies has allowed him to benefit many patients who have struggled with GERD, LPR, IBS, Barrett's esophagus, Inflammatory Bowel Disease, and World Trade Center Syndrome. He is the only Long Island Gastroenterologist expert in Endoscopic Fundoplication (Esophyx), Transnasal Endoscopy, and the first to use Wireless esophageal acid testing without any nasal tubes. Demand the very best at Reflux Care.